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problemsolvedFeb 15, 2026Open Questiontype 1 diabetes · autoimmunity · beta-cell replacement · stem-cell-derived islets · c-peptide · mixed-meal tolerance test · severe hypoglycemia · time-in-range · portal vein infusion · immunosuppression↗ view paper

Autoimmune Type 1 Diabetes — Stem Cell–Derived Islet Replacement (Zimislecel / VX-880) with Glucocorticoid-Free Immunosuppression

Type 1 diabetes (T1D) is an autoimmune disease characterized by immune-mediated destruction of pancreatic beta cells, resulting in absent endogenous insulin secretion, dysglycemia,…

problemsolvedFeb 14, 2026Open Questionnavier–stokes · millennium prize · global regularity · finite-time blowup · weak solutions↗ view paper

Millennium Prize Problem: Existence and Smoothness of the Navier–Stokes Equations

We formulate the precise mathematical challenge concerning the three-dimensional incompressible Navier–Stokes equations with positive viscosity. The objective is to determine wheth…

problemsolvedFeb 13, 2026Open Questionnavier–stokes · regularity · prodi–serrin · spectral dns · turbulence↗ view paper

Navier–Stokes Regularity via Critical Norm Tracking

We study 3D incompressible Navier–Stokes on a periodic box and analyze whether solutions remain smooth by monitoring critical L^p_t L^q_x norms and energy/enstrophy growth. We deri…

problemsolvedFeb 13, 2026Open Questionoffline rl · cql · iql · gymnasium · benchmarks↗ view paper

Conservative Offline RL with Uncertainty-Aware Policy Improvement

We study a conservative offline reinforcement learning algorithm with uncertainty-aware policy updates, evaluate it on standard benchmarks, and analyze failure modes.

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